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- W2348654632 abstract "Objective: To evaluate the therapeutic effect of transfection of human vascular endothelial growth factor (VEGF) gene intobleomycin- induced sclerotic skin of mice. Methods: Mouse model of sclerotic skin was established by local injection ofbleomycin, and VEGF165 gene was transfected into the sclerotic skin in mice applying electroporatic technique. Then VEGF ex-pression was detected by immunohistochemistry and in situ hybridization, and dermatohistologic changes of the skin after trans-fection of VEGF165 gene were observed. Results: Compared with the non- transgenic mice, hair growth on the back of trans-genic mice was increased. Histopathology showed an increase in the number of hair follicles, which was 12.0±1.6/field, higherthan the non-transgenic mice (P0.05). The thickness and angiogenesis of dermis were increased as well. The epidermis anddermis of transgenic mice exhibited an increased expression of VEGF165 gene by immunohistochemistry and in situ hybridiza-tion. Conclusions: Electroporatic technique could be applied to transfect exogenous gene into the sclerotic skin of mice, andthe expression of exogenous gene is effective. The hair growth of sclerotic skin in mice is increased and atrophic dermis couldbe renewed with transfected exogenous VEGF165 gene." @default.
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- W2348654632 date "2005-01-01" @default.
- W2348654632 modified "2023-09-25" @default.
- W2348654632 title "The effects of transfection of human VEGF165 gene with electroporatic technique into bleomycin-induced sclerotic skin in mice" @default.
- W2348654632 hasPublicationYear "2005" @default.
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