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- W2348654725 abstract "Objective: To study the regulatory effect of glutamate on post-ischemia intestinal and cerebral inflammatory responses in a model of ischemic and excitotoxic insults. Methods: Adult male rats were subjected to 15-min tamping of bilateral carotid arteries and intraperitoneal injection of monosodium glutamate(MSG).Hemodynamic parameters were continuously during the whole course of the induced cerebral ischemia.Six hours later,plasma and cerebral and intestinal tissues were collected,and values of tumor necrosis factor alpha(TNF-α) and the activity of nuclear factor kappa B(NF-κB) were determined by enzyme-linked immunosorbance assay(ELISA) and electrophoretic mobility shift assay(EMSA) respectively.Results: The rats treated with MSG displayed statistically higher levels of TNF-α in the cerebral and intestinal tissues than the controls(P0.05),while those treated with both cerebral ischemia and MSG showed significantly lower levels of TNF-α than the MSG-treated ones(P0.05),with a good correlation between TNF-α values and NF-κB activities.Conclusion:Glutamate up-regulates cerebral and intestinal inflammatory responses after ischemia,probably through the NF-κB signal transduction pathway." @default.
- W2348654725 created "2016-06-24" @default.
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- W2348654725 date "2007-01-01" @default.
- W2348654725 modified "2023-09-28" @default.
- W2348654725 title "Glutamate up-regulates inflammatory responses of intestine and brain after focal cerebral ischemia" @default.
- W2348654725 hasPublicationYear "2007" @default.
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