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- W2348656550 abstract "【Objective】To study the reversal effect of toremifene on cisplatin resistance in human lung adenocarcinoma cell lines A549/DDP and to approach the relationship with expression of multidrug resistance-associated protein(MRP).【Methods】The cytotoxic effects of these agents in human lung adenocarcinoma cell line A549/DDP were measured by MTT assay.The expressions of MRP were assessed by immunocytochemistry methods.【Results】In 5 μmol/L、2.5 μmol/L toremifene groups,the inhibition rate was 5.39%、1.43% in A549/DDP respectively,no significant differences of the inhibition rate were observed as compared with control group(P0.05).≥10 μmol/L toremifene could inhibit the growth of A549/DDP cell lines(P0.01).The IC_(50) to cisplatin was decreased from 1.764μg/ml to 0.588μg/ml,1.047μg/ml respectively,and the resistance to cisplatin was reversed by 5 μmol/L and 2.5 μmol/L toremifene visibly in A549/DDP(P0.01),the reversal folds were 3.001 and 1.686 respectively.MRP was over expression in A549/DDP cell.5 μmol/L and 2.5 μmol/L toremifene plus cisplatin could down-regulate the expression of MRP,the significant differences of expression rate were observed as compared with the no-drug and cisplatin group(P0.01).(【Conclusion】)Toremifene not only can inhibit the growth of human lung adenocarcinoma cell lines A549/DDP,but also can reverse the resistance to cisplatin in A549/DDP cell lines.Toremifene down-regulates the expression of MRP to reverse resistance to cisplatin in A549/DDP possibly." @default.
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- W2348656550 date "2006-01-01" @default.
- W2348656550 modified "2023-09-26" @default.
- W2348656550 title "The Reversal Effect of Toremifene on Cisplatin Resistance in Human Lung Adenocarcinoma Cell Lines A549/DDP" @default.
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