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- W2348657943 abstract "Objective To compare the effects of controlled hypotension respectively with nicardipine and nitroglycerin on cerebral oxygen metabolism in intracranial aneurysm clipping surgery.Methods 40 patients,involved in this randomized,controlled and double-blind trail,undergoing intracranial aneurysm clipping surgery were devided into Nicardipine(Ⅰ) Group and Nitroglycerin(Ⅱ) Group with 20 cases each.Control hypotension at the moment of cutting duramater.Blood gas analyses were performed at the time of T0、T1、T2 and T3,respectively corresponding to the moment of cutting duramater,aneurysm isolation completed,aneurysm clipping done and 20 min after controlled hypotension,by taking samples from radical arteries and jugular vein bulbs.Record the values of PaO2,PjvO2,SaO2,SjvO2,Hab,Hjvb and calculate the values of Da-jvO2 and COER.Rsecults Blood pressures were kept at a desirable level without significant difference(P0.05).Heart rates in both groups increased obviously(P0.01)without intergroup difference(P0.05) during controlled hypotension.Compared with T0 and T3,the values of SjvO2 at T1 and T2 increased significantly(P0.05 or0.01) whereas the values of Da-jvO2 and COER decreased significantly(P0.01) in groupⅠ.The values of SjvO2,Da-jvO2 and COER at T1 and T2 were no significant difference with its values at T0 and T3 in group Ⅱ(P0.05).Compared with group Ⅱ,the values of SjvO2 at T2 and T3 were significantly higher(P0.05) whereas the values of Da-jvO2 and COER were significantly lower(P0.05) in group Ⅰ.Conclusion Both nitroglycerin and nicardipine can be safely used for controlling hypotension in intracranial aneurysm clipping surgery.But the later can effectively decrease cerebral oxygen metabolism and improve cerebral oxygenation which is superior to the former in terms of cerebral protection." @default.
- W2348657943 created "2016-06-24" @default.
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- W2348657943 date "2012-01-01" @default.
- W2348657943 modified "2023-09-24" @default.
- W2348657943 title "Effects of nicardipine and nitroglycerin on cerebral oxygen metabolism during controlled hypotension in intracranial aneurysm clipping surgery" @default.
- W2348657943 hasPublicationYear "2012" @default.
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