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- W2348660101 abstract "Objective Approach the protection mechanism of PUFA(polyunsaturated fatty acid) on the intestinal barrier of rats with obstructive jaundice.Methods The grown-up health rats,were divided into Sham-operation group,control group and experimental group stochastically.Obstruction jaundice model were made in control group,experimental group.The rats in sham-operation group and experimental group were feed with standard fodder,while PUFA were added in the experimental group.Improved limulus lysate test was used to detect endotoxemia level;benzoate-caffeine colorimetric method was used to determined direct bilirubin contents;Immunohistochemical SABC method determined small intestinal mucous membrane inherent IgA+ cell number,hybridization in situ method determined IL-6mRNA cell number.Results The endotoxine and direct bilirubin content of control group were obviously higher than that of sham-operation group(P0.01,P0.001),the endotoxine and direct bilirubin content of experimental group were lower than that of control group obviously(7d and 14d compared,P0.01,P0.05);The intestinal mucous membrane inherent IgA+ cell and IL-6mRNA+ cell number reduced obviously under the obstruction jaundice condition,but experimental group were higher than that of control group obviously(P0.01,P0.05).Conclusion PUFA may reduce the intestinal mechanical barrier function harm which causes by the obstruction jaundice,increases the intestinal mucous membrane inherent level IgA+ cell and IL-6 mRNA+ cell number,reduces the intestinal bacterium content,has the improvement function to the obstruction jaundice prognosis." @default.
- W2348660101 created "2016-06-24" @default.
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- W2348660101 date "2008-01-01" @default.
- W2348660101 modified "2023-09-24" @default.
- W2348660101 title "The Experimental Study on the Protection Effect of PUFA on the Intestinal Barrier with Obstructive Jaundice" @default.
- W2348660101 hasPublicationYear "2008" @default.
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