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- W2348664605 abstract "The relaxant effect and its mechanism of dehydrocorydaline(DHC) was studied on the isolated thoracic aorta rings in rats. DHC showed relaxant effects on thoracic aorta with intact or without endothelium. The contraction responses induced by norepinephrine(NE), KCl, and Ca 2+ was antagonized by 12.5 to 200 μmol·L -1 DHC in a non-competitive manner. The pD′ 2 values were 5.12, 3.83, 3.49, respectively. In Ca 2+-free modified Krebs solution, the contraction of two components induced by NE were inhibited significantly by 25 μmol·L -1 DHC. The effect features of DHC mentioned above were just like that of verapamil in the same experimental conditions. The results suggest that the relaxant effect of DHC on rat′s thoracic aorta be not dependent on endothelium, and be closely related to the blockage of Ca 2+ entry through both potential-dependent calcium channel and receptor-operating calcium channel, and to the inhibition of intracellular Ca 2+ release." @default.
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- W2348664605 date "2001-01-01" @default.
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- W2348664605 title "Effect of dehydrocorydaline on isolated thoracic aorta in rats" @default.
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