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- W2348692743 abstract "Objective To investigate the correlation of serum pregnancy-associated plasma protein-A(PAPP-A)with high-senstivity C-reactive protein(hsCRP)and tumornecrosis factor-α(TNF-α)in patientswith acute coronary syndromes(ACS).Methods Serum PAPP-A,hsCRP and TNF-αlevelswere determined in eighteen patientswith unstable angina(UAP group),thirty-seven patientswith acutemyocardial infarction(AMI group),fifteen patientswith stable angaina(SAP group)and fifteen healthy subjects(control group).Results Serum PAPP-A levelswere significantly higher inUAP group and AMI group than those in SAP group and control group(P0.01 for each).The PAPP-A leveldid notdiffer significantly between SAP group and controlgroup(P0.05).Serum PAPP-A level in cTnT-negative patientswas also significantly higher than those in controlgroup(P0.01)and SAP group(P0.05).Serum hsCRP andTNF-αlevelswere significantly higher in SAP group than those in controlgroup and inUAP group or higher in UAP group than those in SAP group and control group,but lower than that in AMI group.The level of serum PAPP-A inACS patientswas positively correlatedwith serum hsCRP and TNF-αlevels(r=0.616,0.712,P0.01).Conclusion PAPP-A is associatedwith inflammationwhichmay detectplaque unstability and rupture before cTnT is not increased." @default.
- W2348692743 created "2016-06-24" @default.
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- W2348692743 date "2009-01-01" @default.
- W2348692743 modified "2023-09-24" @default.
- W2348692743 title "The Study of The Clinical Relevance Between The Serum Level of Pregnancy-associated Plasma protein-A And Degree of Acute Coronary Syndrome" @default.
- W2348692743 hasPublicationYear "2009" @default.
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