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- W2348733079 abstract "AIM: To investigate the expression of MAT1 protein in pancreatic cancers and the relationship between MAT1 and clinicopathological features of pancreatic cancers. METHODS: 94 surgical specimens, including 70 pancreatic cancers, 10 pancreatic benign tumors, 14 chronic pancreatitis and 10 autopsy normal pancreas tissues, were analyzed immunohistochemically, and then MAT1 expression and clinicopathological features were compared. RESULTS: MAT1 was expressed mainly in the cancer cells,and also in the fibroblasts, where it was localized within the cytoplasm and nuclear envelope. MAT1 expression was found in 75.7% (53/70) of the cancers, but not detected or weakly expressed in control tissues. There was a significant difference in expression of MAT1 among the above four tissues (P0.01). Furthermore, MAT1 expression showed a significant correlation with TNM stage (P0.05), but no correlation with other clinicopathological features. CONCLUSION: The MAT1 protein that is up-regulated in the pancreatic cancer may involve in pancreatic carcinogenesis, and MAT1 in primary lesion may be an useful marker for evaluating prognosis in patients with pancreatic cancer. [" @default.
- W2348733079 created "2016-06-24" @default.
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- W2348733079 date "2005-01-01" @default.
- W2348733079 modified "2023-09-23" @default.
- W2348733079 title "Relationship between MAT1 expression and clinicopathological features of pancreatic cancers" @default.
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