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- W2348753479 abstract "Objective To investigate the role of caspase 3 in ATP depleted apoptosis in renal tubular epithelial cells (RTEC). Methods To induce apoptosis, REC were subjected to 60 min ATP depletion followed by recovery. Wild-type bcl-2 was overexpressed by infecting opossum kidney (OK) cells with adenovirus containing wild-type human bcl-2. Apoptotie cells were detected with Hoechst 33342 dye. Flow cytometry was used to quantify apoptosis and necrosis. Active caspase 3 and bcl-2 degradation were assessed by Western blot. Results ATP depletion and recovery resulted in activation of caspase 3 and the progressive accumulation of bcl-2 cleavage products and apoptosis. Overexpression of bcl-2 ameliorated apoptosis in the ATP-depleted RTEC followed by recovery. Caspase 3 reproduced the effect of caspase 3 on bcl-2 cleavage, whereas caspase 3 specific inhibitor DVED prevented bcl-2 cleavage in vitro. Conclusion Caspase 3 activition and mediated-bcl-2 degradation are likely to contribute to ATP depletion-induced apoptosis in RTEC." @default.
- W2348753479 created "2016-06-24" @default.
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- W2348753479 date "2005-01-01" @default.
- W2348753479 modified "2023-09-26" @default.
- W2348753479 title "The role of caspase 3-dependent bcl-2 degradation in ATP depleted apoptosis in renal epithelial cells" @default.
- W2348753479 hasPublicationYear "2005" @default.
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