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- W2348761988 abstract "Objective:To explore the influence of Janus kinase inhibitor AG490 on phosphorylation of extracellular signal-regulated protein kinase(ERK) in the human breast cancer cell line MDA-MB-231,so as to discuss the effect of JAK on ERK signal transduction pathway and on invasion/metastasis of breast cancer cells.Methods: MDA-MB-231 cells were treated with Janus kinase inhibitor AG490;MTT assay was used to examine the proliferation of MDA-MB-231 cells and the adhesion of MDA-MB-231 cells to artificial basement membrane matrigel after AG490 treatment.Invasion and metastasis of MDA-MB-231 cells were evaluated with transwell chamber after treated with AG490.The expression of P-ERK and MMP-9 protein was determined by Western blotting assay.Results: AG490 inhibited the proliferation of MDA-MB-231 cells in a time-and dose-dependent manner;AG490 also depressed the adhesion,invasion and metastasis of MDA-MB-231 cells.Meanwhile,the expression of P-ERK and MMP-9 protein was decreased after treatment with AG490.Conclusion: Our study indicates that JAK kinase can affect the activity of ERK signal transduction pathway through the phosphorylation of ERK.The inhibitory effects of JAK kinase on MMP-9 expression and invasion of breast cancer cells are associated with the blocking of the ERK signaling pathway." @default.
- W2348761988 created "2016-06-24" @default.
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- W2348761988 date "2008-01-01" @default.
- W2348761988 modified "2023-09-26" @default.
- W2348761988 title "Effect of Janus kinase inhibition on extracellular signal-regulated protein kinase during invasion and metastasis of human breast cancer cell MDA-MB-231" @default.
- W2348761988 hasPublicationYear "2008" @default.
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