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- W2348769653 abstract "Objective To study changes of plasma cortisol level after pediatric cardiac surgery with cardiopulmonary bypass(CPB)and explore risk factors for adrenal insufficiency(AI)after surgery.Methods In a prospective study,80 children with congenital heart disease undergoing CPB were enrolled from Mar.to Oct.in 2006.Possible preoperative and intra-operative risk factors were recorded.The plasma levels of cortisol were determined by radioimmunoassay.The plasma levels of adrenocortiectrophic hormone(ACTH)were detected by chemiluminescence.Results Plasma cortisol concentration was signit cantly increased immediately and 6 hours after surgery,compared with pre-operation P0.05.Plasma cortisol concentrations was significantly decreased 24,48 and 72 hours after surgery.Plasma ACTH concentrations decreased significantly 24 and 48 hours after surgery,compared with pre-operation P0.05.The incidence of AI was 41%.In AI children,their means of age,cardiopulmonary bypass time,aortic cross-clamp time and pulse oxygen saturation[Sp(O2)]were significantly different from those of other children.Age and CPB time were independent risk factors.Conclusions Plasma cortisol concentration increases early after surgery,then decreases from 24 hours,while some patients have AI after surgery.Age,CPB time are the independent risk factors for AI after pediatric cardiac surgery with CPB." @default.
- W2348769653 created "2016-06-24" @default.
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- W2348769653 date "2007-01-01" @default.
- W2348769653 modified "2023-09-23" @default.
- W2348769653 title "Effect Factors of Adrenal Insufficiency after Operation Undergoing Cardiopulmonary Bypass in Children with Congenital Heart Disease" @default.
- W2348769653 hasPublicationYear "2007" @default.
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