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- W2348771839 abstract "Objective To explore the mechanism of immunomodulatory activity of Polyporus umbellatus polysaccharides(PPS) on murine bone marrow dendritic cells(BMDC).Methods BMDC phenotype and the function indexes were observed by 3H-TdR incorporation,ELISA,and flow cytometry.Results Compared with the negative group,PPS could increase the co-expression of CD11c and CD86 molecules on dendritic cells(DC) surface and the production of IL-12 and IL-10 in a dose-dependent manner.PPS also enhanced matured BMDC capacity of T cell initial activation and decreased phagocytosis of BMDC.Anti-Toll-like receptor 4(TLR4),but not anti-TLR2 or complement receptor 3(CR3) monoclonal antibodies inhibited PPS-induced production of IL-12 p40 and blocked the combination between fluorescence-labeled PPS(f-PPS) and BMDC.Conclusion The data demonstrate that PPS could promote the activation of murine BMDC via TLR4 and maturation of immunomodulationy activity." @default.
- W2348771839 created "2016-06-24" @default.
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- W2348771839 date "2011-01-01" @default.
- W2348771839 modified "2023-09-23" @default.
- W2348771839 title "Effect of Polyporus umbellatus polysaccharides on activation of murine bone marrow dendritic cells via Toll-like receptor 4" @default.
- W2348771839 hasPublicationYear "2011" @default.
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