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- W2348778884 abstract "OBJECTIVE: To evaluate role of protein Bcl-2 in the oxidative injury induced by radiotherapy or chemotherapy. METHODS:We employed the rat models for radiotherapy and chemotherapy. For each experiment,the rats were divided into four groups:control group,model group,radiotherapy or chemotherapy group,and protection 60 group. The rats for radiotherapy experiment received local radiation of Co γ with the accumulative dosage of 47 Gy. The rats for chemotherapy experiment received doxorubicin(2 mg/kg) by intraperitoneal injection every two days. The protection groups received multiple antioxidants(Antitoxin 60 mg/kg+Vit E 20 mg/kg+Tannin 2.5 mg/kg) by gavage every day. These treatments lasted 5 weeks for radiotherapy experiment and 8 weeks for chemotherapy experiment. At the end of the experiments,all of the rats were sacrificed and the specific tissues were fixed to cut sections. The expression of protein Bcl-2 was measured by immunohistochemistry and the positive stainings were quantified by optical density analysis. RESULTS:There was a certain positive expression of protein Bcl-2 in the normal rats. Radiotherapy or chemotherapy treatment significantly inhibited the protein Bcl-2 expression(P0.05),in which antioxidant supplementations showed obvious protection(P0.05). CONCLUSION:Protein Bcl-2 was a key target of oxidative injury induced by radiotherapy and chemotherapy,as well as a potential target of antioxidant supplementation to reduce the side effects of radiotherapy and chemotherapy." @default.
- W2348778884 created "2016-06-24" @default.
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- W2348778884 date "2014-01-01" @default.
- W2348778884 modified "2023-09-26" @default.
- W2348778884 title "Role of protein Bcl-2 in the oxidative injury induced by radiotherapy or chemotherapy" @default.
- W2348778884 hasPublicationYear "2014" @default.
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