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- W2348779013 abstract "Objective:To further investigate the role of IGF-1 in regulating integrin signaling pathway,and the mechanism of insulin-like growth factor-Ⅰ in Regulating Embryo Implantation.Methods:The expression of phosphorylated focal adhesion kinase was determined by immunocytochemistry and westem blot based on reference 1.Results:Immunocytochemistry staining showed phosphorylated focal adhesion kinase was expressed in the trophoblast cells treated with IGF-Ⅰ.The results of immunoblotting demonstrated that tyrosine phosphorylation of focal adhesion kinase(pFAK)was activated following IGF-Ⅰ stimulation,and pFAK exhibited time-response and dose-dependent manner,but the antibody against β3 integrin reduced the activation of pFAK.Conclusion:IGF-Ⅰ promote adhesion of trophoblast cells to fibronectin by activating phosphorylated focal adhesion kinase and integrin signaling pathway." @default.
- W2348779013 created "2016-06-24" @default.
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- W2348779013 date "2007-01-01" @default.
- W2348779013 modified "2023-09-28" @default.
- W2348779013 title "Mechanism of insulin-like growth factor-I in regulating embryo implantation" @default.
- W2348779013 hasPublicationYear "2007" @default.
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