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- W2348781330 abstract "Objective To analyze the effects of Toxoplasma gondii infection on the hormones by detecting the concentration of insulin-like growth factors(IGF-Ⅱ) and the levels of 11β-hydroxysteroid dehydrogenase-2(11β-HSD2)expression in the placentae of pregnant BALB/c mice.Methods Pregnant mice were infected with T.Gondii on the 8th day of pregnancy,and pregnant mice were sacrificed on the 12th,14th,and 16th day of pregnancy.The placentae of pregnant mice were collected,and the percentage of IGF-Ⅱ was determined with ELISA.The level of 11β-HSD2 expression was determined immunohistochemically.Results An IGF-Ⅱ assay showed that the concentration increased as pregnancy continued in the normal control group but first decreased and then increased in the infected group.Differences in IGF-Ⅱ levels at different days of gestation were statistically significant(P0.05) in both groups,and differences in those levels at the same days of gestation were statistically significant(P0.05).The expression of 11β-HSD2 increased as pregnancy continued in the normal control group.Differences in 11β-HSD2 levels at different days of gestation were statistically significant(P0.05)in the normal control group,and levels did not differ(P0.05) in the infected group.Differences in 11β-HSD2 levels at the same days of gestation were statistically significant(P0.05).Conclusion In pregnant mice infected with T.gondii,the secretion of the 11β-HSD2 and IGF-Ⅱ decreased.This may be due to the concentration of GC in mice fetuses,blood vessels,and glycogen synthesis and transport in the placenta.These changes may delay the growth of fetal mice in the womb." @default.
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- W2348781330 date "2012-01-01" @default.
- W2348781330 modified "2023-09-25" @default.
- W2348781330 title "Effects of Toxoplasma gondii infection on placenta hormones in pregnant BALB/c mice" @default.
- W2348781330 hasPublicationYear "2012" @default.
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