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- W2348783911 abstract "Objective To explore the improving potential of immature myeloid dendritic cell(iMDC)pulsed with P258-73aa peptide(P258-73aa-iMDC)in experimental autoimmune neuritis(EAN),and to explore the role of Th1/Th17 cells polarization in this tolerance therapy by detecting the expression of IL-17 and IFN-γ mRNA.Methods P258-73aa21 was pulsed with iMDC in vitro to get P258-73aa-iMDC.Rats of each group were immunized with P253-78aa and CFA.7 days before immunization,each group was injected with PBS or iMDC or P258-73aa-iMDC respectively.Clinical scores of each group and histopathological changes were evaluated and the lymphocyte proliferation response was assayed;IL-17 and IFN-γ mRNA in spleen,lymph node and sciatic nerves were measured by RT-PCR.Results The P258-73aa-iMDC interferred group had lower average clinical score and suppressed antigen specific lymphocyte proliferation,as well as milder infiltration by the inflammatory cells in sciatic nerves.Meanwhile,the expression of IL-17/IFN-γ mRNA in spleen,lymph node and sciatic nerves were also decreased.Conclusion The protective effect of P258-73aa-iMDC could be associated with the inhibition of lymphocyte proliferation and IL-17,IFN-γ through the polarization of Th1/Th17 cells,which is probably one of the tolerance mechanism of P258-73aa-iMDC in EAN." @default.
- W2348783911 created "2016-06-24" @default.
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- W2348783911 date "2009-01-01" @default.
- W2348783911 modified "2023-09-24" @default.
- W2348783911 title "Effect of iMDC pulsed with P258-73 peptide on the Th17/Th1 cells polarization in EAN" @default.
- W2348783911 hasPublicationYear "2009" @default.
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