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- W2348789039 abstract "The expression of three heat shock proteins (HSPs)-HSP 90a, HSP 70 and HSP 27 in celis obtained from 22 patients with leukemia, erythroleukemia cell line K562, and normai blood celis was observed by means of RNA dot blot analysis. The results showed that the expression of the HSP 27 gene was enhanced in 4 cases with acute lymphoid leukemia (ALL), 7 cases with acute nonlymphoid leukemia (ANLL) and 2 cases with myelodysplastic syndrome (MDS) as compared with the normai blood celis, yet there was no significant differences on the HSP 27 expression between the ALL and ANLL celis. The expression of HSP 70 in all the cells of 5 ALL and ANLL patients was much lower than that in the normai celis, except l case with ALL and l case with MDS, which enhanced obviously. All of the celis in the cases including 11 ANLL, 5 ALL and l MDS had higher HSP 90a expression than the normai celis. The enhanced expression of HSP 90a in leukemia celis may be associated with the active and indefinite proliferation of leukemia celis. Our results also suggest that the high expression of the HSP 27 gene may not be confmed to a specific marker of acute leukemia." @default.
- W2348789039 created "2016-06-24" @default.
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- W2348789039 date "1996-01-01" @default.
- W2348789039 modified "2023-09-28" @default.
- W2348789039 title "Study of Heat Shock Protein HSP 90a,HSP 70 and HSP 27 mRNA Expression in Human Acute Leukemia Cells" @default.
- W2348789039 hasPublicationYear "1996" @default.
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