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- W2348790428 abstract "Conjugation of many primary, secondary, and tertiary amine-containing xenobiotics with glucuronic acid can result in the formation of N-glucuronide metabolites. Of the more than 30 UDP-glucuronosyltransferases (UGTs) that have been purified or cloned and expressed, some UGTs many catalyze N-glucuronide formation for primary and secondary amine substrates. The mutation of the UGT1gene complex may explain the inability of some species to form quaternary ammonium-linked glucuronides. The study of reactivity of UGT isoforms to carcinogenic aromatic amines could serve to broaden our understanding the dangerous carcinogenicity of these compounds. For the N-hydroxylated metabolites of carcinogenic arylamines , N-glucuronidation can result in the formation of either inactive metabolites or liable conjugates which can be transported to their target tissue(urinary bladder)where they may be converted to reactive metabolites." @default.
- W2348790428 created "2016-06-24" @default.
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- W2348790428 date "2003-01-01" @default.
- W2348790428 modified "2023-09-24" @default.
- W2348790428 title "Conjugation Reaction of UGTs and N-glucuronic Acid" @default.
- W2348790428 hasPublicationYear "2003" @default.
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