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- W2348830710 abstract "Objective:To observe the effect of icariin(ICA) on cell proliferation,cell cycle,adheration and invasion in SW579 cells and to approach the mechanism of its reversing the malignant phenotype of SW579 cells.Methods:MTT assay was used to explore theeffects of ICA on the proliferation of SW579cells.Reverse transcriptase-polymerase chain reaction was used to examine mRNA levels of inhibitor of differentiation/DNA binding-1(Id-1)and p21 genes.Flow cytometry was used to detect cell cycle of SW579 cells treated by IP.Soft agar colony formation was used to test the anchoring independent growth of SW579 cells.Adhesion between SW579 cells and matrigel was be examined and the Transwell chamber was used to detect the invasion.Results:The inhibition of SW579 cells proliferation treated by ICA was time and concentration dependent in the the concentration range 6.25 mg/L~100 mg/L.The cell cycle status of ICA-treated SW579 cells were significantly different compared with those of the controls.The number of G0/G1-phase cells increased(P=0.0025),and S-phase cells decreased(P=0.001),and the aneuploid content decreased simultaneously.The colony forming efficiency,adhesion rate between SW579 cells and matrigel and invasiveness were reduced remarkably.ICA down-regulated the expression of Id-1and up-regulated the expression level of the downstream effector p21 mRNA.Conclusion:Icariin reversed the malignant phenotype of sw579 cells and induced the differentiation of SW579 cells through down-regulated Id-1,which activate the p21." @default.
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- W2348830710 date "2012-01-01" @default.
- W2348830710 modified "2023-09-26" @default.
- W2348830710 title "Icariin induces the differentiation and reverses the the malignant phenotype of SW579 cells" @default.
- W2348830710 hasPublicationYear "2012" @default.
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