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- W2348834009 abstract "Objective:To establish a method to determine Methyclothiazide in human plasma with liquid chromatographytandem mass spectrometry.Method:0.2 mL plasma was alkalified with NaOH,then extracted with EtOAc(added with 5% isopropanol).The analysis was performed in the multiple reaction monitoring in which Methyclothiazide and Hydrochlorothiazide(IS)were detected through the transition from the precursor to the production(mz 358.2 to mz 321.9;mz 296.3 to mz 268.9).The retention time of Methyclothiazide and Hydrochlorothiazide(IS)were 1.6min and 1.0min.Result:In this method,the endogenous factors do not disturb the determination.Method recovery of Methyclothiazide is 93.7%～105.4%.Intra-assay and inter-assay CV are lower than 6.04%,LOQ is 0.2ngmL(SN≥20:1).Calibrations between 0.2ngmL～51.2ngmL exhibited consistent linearity and reproducibility.Conclusion:The pretreatment of this method is simply and quickly,and analysis has a high specificity and the reagents cost is low,so this method is suitable for the need of pharmacokinetics research and the clinical determination." @default.
- W2348834009 created "2016-06-24" @default.
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- W2348834009 date "2005-01-01" @default.
- W2348834009 modified "2023-09-23" @default.
- W2348834009 title "Liquid chromatography/tandem mass spectrometry for the determination of Methyclothiazide in human plasma" @default.
- W2348834009 hasPublicationYear "2005" @default.
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