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- W2348839996 abstract "AIM To observe angiotensin-converting enzyme 2(ACE2) level in rats with renal interstitial fibrosis induced by adenine,and effects of extract Ginkgo biloba 761(EGb761) on ACE2 expression level.METHODS Twenty-four rats with renal fibrosis were randomly divided into EGb761 group,losartan group and control group(eight rats each group),eighteen rats as normal group.EGb761 group received EGb761 suspension 100 mg/(kg·d),losartan group received losartan suspension 10 mg/(kg·d),and the normal group and control group received the distilled water by gavage.The rats were sacrificed after 30 days' medication,blood,urine and kidneys samples were collected for kidney function,albuminuria and pathomorphology analysis.Immunohistochemistry and Real Time PCR were used to detect the amount of ACE2 protein and mRNA expression.RESULTS Serum creatinine(Scr),blood urea nitrogen(BUN),24-hour urine protein(24hMTP) in the control group were significantly higher than that in the normal group(P0.01).Compared with the control group,Scr,24hBUN and MTP of EGb761 and losartan group decreased significantly(P0.01).Immunohistochemistry and Real Time PCR results showed that renal tissue ACE2 protein of the control group decreased as compared with normal group;while renal tissue ACE2 protein in EGb761 and losartan group was significantly increased compared with control group(P0.01).CONCLUSION EGb761 could lower the serum urea nitrogen and creatinine,and 24 h urinary protein,and increase ACE2 protein and mRNA expression in rat with renal interstitial fibrosis induced by adenine." @default.
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- W2348839996 date "2011-01-01" @default.
- W2348839996 modified "2023-09-23" @default.
- W2348839996 title "Effects of EGb761 on renal tissue ACE2 protein and mRNA expression in adenine-induced renal interstitial fibrosis rats" @default.
- W2348839996 hasPublicationYear "2011" @default.
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