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- W2348842955 abstract "Objective: To investigate the rewarding effect of morphine on newly hatched chicks and the role of dopaminergic mechanisms on the expression of morphine-induced place preference. Methods: Newly hatched male chicks were administrated with morphine (2 mg·kg-1, intraperitoneally) for 4 conditioning trials, 0.25 mg·kg-1 dopamine D 1 receptor antagonist SCH23390 or the same dose of D 2 receptor antagonist raclopride intraperitoneally injected before the expression of place preference. Results: Morphine produced conditioned place preference(CPP) on chicks(P0.01). The injection of SCH23390 (P0.05) but not raclopride(P0.05) abolished the expression of morphine-induced CPP. Conclusion: These results suggest that the rewarding effects of morphine may be highly conserved across species. Chicks might serve as an alternative animal model for investigating drugs of abuse. These data also indicate that D 1 receptor is critically involved in morphine-induced craving." @default.
- W2348842955 created "2016-06-24" @default.
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- W2348842955 date "2004-01-01" @default.
- W2348842955 modified "2023-09-25" @default.
- W2348842955 title "INVOLVEMENT OF DOPAMINE D_1 RECEPTORS ON THE EXPRESSION OFMORPHINE-INDUCED PLACE PREFERENCE IN CHICKS" @default.
- W2348842955 hasPublicationYear "2004" @default.
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