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- W2348851880 abstract "OBJECTIVE:To detect hypermethylation of RASSF1A gene in the tissue and the serum from ovarian tumor patients,and to explore its correlation with ovarian cancer.METHODS:Sixty-five tissue samples and their corresponding serum samples from ovarian tumor patients,10 serum sampales from healthy volunteers were collected for hypermethylation measurement by semi-nested methylation-specific PCR(MSP).RESULTS:Hypermethylation of RASSF1A was present in 20.0%(7/35)of the cancer serum samples and 31.4%(11/35)of the cancer tissues.None of benign ovarian disease tissues and serums was methylated.Hypermethylation of RASSF1A was not found in serum samples from healthy volunteers.There was a statistical association between hypermethylation of RASSF1A in serums and that of RASSF1A in tumor tissues(P 0.01).Hypermethylation of the RASSF1A in serums and the corresponding cancer tissues was not significantly correlated with the clinical stages,histologic cell types,degrees of cell differentiation of the tumor(P 0.05),but it was strongly correlated with lymph node metastasis(P 0.05).CONCLUSION:The result indicated that hypermethylation of the RASSF1A may be a useful marker in the auxiliary diagnosis of ovarian cancer." @default.
- W2348851880 created "2016-06-24" @default.
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- W2348851880 date "2008-01-01" @default.
- W2348851880 modified "2023-09-25" @default.
- W2348851880 title "Detection of aberrant methylation of RASSF1A gene in the tissue and the serum from ovarian tumor patients and its clinical significance" @default.
- W2348851880 hasPublicationYear "2008" @default.
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