Matches in SemOpenAlex for { <https://semopenalex.org/work/W2348862554> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2348862554 abstract "Objective To investigate mutations and the carrying of breast cancer susceptibility gene(BRCA)1 and BRCA2 among patients and their healthy first degree relatives in family constellation of breast cancer in Hebei province.Methods This study involved breast cancer patients treated in the Fourth Affiliated Hospital of Hebei Medical University from June,2002 to May,2008 and their relative,including 59 samples (13 patients and 46 healthy first degree relatives from 12 independent families of Han Nationality in which 2 or more first or second degree relatives had breast cancer history.Four BRCA1/BRCA2 mutation hot spots (BRCA1:Exon2,11,20;BRCA2:Exon11) commonly reported in literature were detected by extracting DNA from peripheral blood,using PCR-SSCP and gene se quencing technology.Results One BRCA1 mutation site (4193insA) and one BRCA2 mutation site(5329insT)were found with frame shift mutations;four variation sites (BRCA1:4165TA and 287GC,BRCA2:6251GT and 5416CA) were observed.In every families which carrying 4193insA,5329insT,287GC individually,3 cases which had breast cancer were found.Conclusion BRCA1(4193insA),BRCA2(5329insT),BRCA1:4165TA and 287GC and BRCA2:6251GT and 5416CA could be the mutation sites in familial breast cancer in Hebei Province.The families carrying those sites show a higher incidence of breast cancer.Therefore,close follow-ups or surgical or drug interventions are recommended for the first-degree relatives of the breast cancer patients." @default.
- W2348862554 created "2016-06-24" @default.
- W2348862554 creator A5005492357 @default.
- W2348862554 date "2012-01-01" @default.
- W2348862554 modified "2023-09-23" @default.
- W2348862554 title "BRCA1 and BRCA2 gene mutations in familial breast cancer" @default.
- W2348862554 hasPublicationYear "2012" @default.
- W2348862554 type Work @default.
- W2348862554 sameAs 2348862554 @default.
- W2348862554 citedByCount "0" @default.
- W2348862554 crossrefType "journal-article" @default.
- W2348862554 hasAuthorship W2348862554A5005492357 @default.
- W2348862554 hasConcept C104317684 @default.
- W2348862554 hasConcept C120665830 @default.
- W2348862554 hasConcept C121332964 @default.
- W2348862554 hasConcept C121608353 @default.
- W2348862554 hasConcept C126322002 @default.
- W2348862554 hasConcept C143998085 @default.
- W2348862554 hasConcept C2779862289 @default.
- W2348862554 hasConcept C2781179581 @default.
- W2348862554 hasConcept C501734568 @default.
- W2348862554 hasConcept C530470458 @default.
- W2348862554 hasConcept C54355233 @default.
- W2348862554 hasConcept C61511704 @default.
- W2348862554 hasConcept C71924100 @default.
- W2348862554 hasConcept C86803240 @default.
- W2348862554 hasConceptScore W2348862554C104317684 @default.
- W2348862554 hasConceptScore W2348862554C120665830 @default.
- W2348862554 hasConceptScore W2348862554C121332964 @default.
- W2348862554 hasConceptScore W2348862554C121608353 @default.
- W2348862554 hasConceptScore W2348862554C126322002 @default.
- W2348862554 hasConceptScore W2348862554C143998085 @default.
- W2348862554 hasConceptScore W2348862554C2779862289 @default.
- W2348862554 hasConceptScore W2348862554C2781179581 @default.
- W2348862554 hasConceptScore W2348862554C501734568 @default.
- W2348862554 hasConceptScore W2348862554C530470458 @default.
- W2348862554 hasConceptScore W2348862554C54355233 @default.
- W2348862554 hasConceptScore W2348862554C61511704 @default.
- W2348862554 hasConceptScore W2348862554C71924100 @default.
- W2348862554 hasConceptScore W2348862554C86803240 @default.
- W2348862554 hasLocation W23488625541 @default.
- W2348862554 hasOpenAccess W2348862554 @default.
- W2348862554 hasPrimaryLocation W23488625541 @default.
- W2348862554 hasRelatedWork W1979297902 @default.
- W2348862554 hasRelatedWork W1987355921 @default.
- W2348862554 hasRelatedWork W1992211028 @default.
- W2348862554 hasRelatedWork W2034421645 @default.
- W2348862554 hasRelatedWork W2034765965 @default.
- W2348862554 hasRelatedWork W2034903708 @default.
- W2348862554 hasRelatedWork W2085210663 @default.
- W2348862554 hasRelatedWork W2121154077 @default.
- W2348862554 hasRelatedWork W2358404385 @default.
- W2348862554 hasRelatedWork W2377505320 @default.
- W2348862554 hasRelatedWork W2389392963 @default.
- W2348862554 hasRelatedWork W25226527 @default.
- W2348862554 hasRelatedWork W2803063169 @default.
- W2348862554 hasRelatedWork W2912965504 @default.
- W2348862554 hasRelatedWork W3140001743 @default.
- W2348862554 hasRelatedWork W3153030865 @default.
- W2348862554 hasRelatedWork W3172910523 @default.
- W2348862554 hasRelatedWork W3208948198 @default.
- W2348862554 hasRelatedWork W2106518238 @default.
- W2348862554 hasRelatedWork W2422888147 @default.
- W2348862554 isParatext "false" @default.
- W2348862554 isRetracted "false" @default.
- W2348862554 magId "2348862554" @default.
- W2348862554 workType "article" @default.