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- W2348877600 abstract "Objective To study the effects of acute stimulation with morphine on sIPSC and mIPSC of hippo campus neurons.Methods Using the whole cell voltage-clamp technique on hippocampus neurons. Results The amplitude and the frequency of mIPSC,were decreased by acute stimulaiton with morphine in hippocampus neurons. Naloxone bloced the effect of morphine.Conclusion Morphine inhibits the action potential independent release of GABA through a direct action on interneuronal synaptic terminals;morphine also reduces the amplitude of IPSCs action potential evoked and GABA mediated, as well as decreases their frequency. This suggests that the inhibition effect of morphine on non action potential-dependent GABA release reveals a mechanism that contributes to reduce action potential evoked GABA release, thereby decreasing synaptic inhibition." @default.
- W2348877600 created "2016-06-24" @default.
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- W2348877600 date "2002-01-01" @default.
- W2348877600 modified "2023-09-25" @default.
- W2348877600 title "Effects of morphine on IPSC of hippocampus neurons of neonatal rat" @default.
- W2348877600 hasPublicationYear "2002" @default.
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