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- W2348892535 abstract "Purpose The study was aimed exploring whether nitric oxide synthase inhibitor-N~C-nitro-L-arginine methyl ester(L-NAME)reduces hearing loss in acoustic trauma.Methods Sixty guinea pigs(350～400 g)were divided randomly into three groups(control group,noise+saline group,noise+L-NAME group).Auditory brainstem responses (ABRs)were measured before and 72 h after noise exposure(4 kHz octave band,115 dB SPL 5 h).The cochleas were made to determine the level of NO and reactive immunohistochemistry intensity of inducible nitric oxide synthase(iNOS)was observed.Results The thresholds at hearing in the control group were relatively stable,while the hearing thresholds in the noise+saline group were significantly higher than those in the noise+L-NAME group(P0.05).The NO level of the cochlear tissue in the noise+saline group was significantly higher than that in the control group(P0.05),while the NO level in the noise+L-NAME group was significantly lower than that in the noise+saline group(P0.05).The immunoreactivity of iNOS was more intense in the noise+saline group than that in the noise+L-NAME group.Conclusion Nitric oxide catalyzed by iNOS plays an important role in the formation of noise induced hearing loss(NIHL)in acoustic trauma and L-NAME reduces NIHL through inhibiting the activity of iNOS." @default.
- W2348892535 created "2016-06-24" @default.
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- W2348892535 date "2004-01-01" @default.
- W2348892535 modified "2023-09-27" @default.
- W2348892535 title "The Protective Effects of Nitric Oxide Synthase Inhibitor on the Noise-induced Hearing Loss in Acoustic Trauma" @default.
- W2348892535 hasPublicationYear "2004" @default.
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