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• W2348898106 abstract "BACKGROUND OBJECTIVE: Gefitinib,an anilinoquinazoline,is an ora ll y active,selective epidermal growth factor receptor(EGFR) tyrosine kinase inhibi tor,which has been approved for the treatment of advanced non-small cell lung cancer. We have found that the proliferation of nasopharyngeal carcinoma (NPC) c ell lines CNE1,CNE2,and SUNE1 was inhibited by Gefitinib.The present study was d esigned to evaluate the effect of Gefitinib alone or in combination with cisplat in (DDP) on NPC CNE2 xenografts. METHODS: Exponentially growing CNE2 cells were prepared into cell suspension (1×107 cells/ml). Suspension of 200 靗 of CNE2 c ells was injected s.c. into the right flank area of the mice. After 7 days,when well-established tumors of 100-200 mm3 were detected,mice were randomized into five groups: control group,Gefitinib (100 mg/kg) group,Gefitinib (200 mg/kg) gr oup,DDP group,and Gefitinib (100 mg/kg) plus DDP group. Gefitinib was administer ed by oral gavage on days 1-5 of each week for 4 weeks. DDP was administered i. p. once a week for 4 weeks. Tumor volume was determined by direct measurement wi th caliper and calculated by the formula 1/2×(large diameter)×(small diameter) 2. The mice were sacrificed at two days after the treatment ended; tumor masses were removed and weighed. The tumor inhibition rates were calculated. The studen ts test was used to evaluated the statistical significance of the results. RES ULTS: Growth curves showed that tumor masses of control group grew more rapidly than ones of every treatment group. The average tumor volume was significantly s maller in Gefitinib (200 mg/kg) group than in control group (P=0.02). The averag e tumor volume had no significant difference between Gefitinib (100 mg/kg) group and control group. The average tumor volume of DDP or Gefitinib (100 mg/kg) plu s DDP group was smaller than that of control group(P=0.007 and 0.001,respectivel y). The average tumor volume had no significant difference between DDP and Gefit inib (100 mg/kg) in combination with DDP group. The tumor inhibition rates of Ge fitinib (100 mg/kg) group,Gefitinib (200 mg/kg) group,DDP group,and Gefitinib (1 00 mg/kg) plus DDP group were 26.3%,30.6%,45.7%and 54.8%,respectively. The a verage tumor weight after treatment had no significant difference between Gefiti nib (100 mg/kg) group and control group.The average tumor weights of Gefitinib ( 200 mg/kg) group,DDP group,Gefitinib (100 mg/kg) plus DDP group were all smaller than that of control group. The average tumor weight had no significant differe nce between DDP group and Gefitinib (100 mg/kg) plus DDP group. CONCLUSION: Gefi tinib could inhibit the growth of NPC CNE2 xenografts. Gefitinib in combination with DDP did not significantly potentiate the effect of DDP on NPC CNE2 xenograf ts." @default.
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• W2348898106 date "2004-01-01" @default.
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• W2348898106 title "[Effect of epidermal growth factor receptor-selective tyrosine kinase inhibitor gefitinib on nasopharyngeal carcinoma xenografts]." @default.
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