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- W2348908259 abstract "Objective To observe the effect of N-acetylcysteine( NAC) on pulmonary injury under simulated weightlessness in rats. Methods Tail-suspension method was used to establish the models of weightless simulation in rats. A total of 24 clean Wistar rats were randomly divided into group A,B and C( n = 8 for each group). Group B was treated with NAC( 300 mg / kg) by intragastric administration every day from the first day,while group A and C were treated with same volume of sterile water via intragastric injection. The models of weightless simulation were established in group A and B by tail-suspension method after the rats had been administrated for 2 d,while the rats in group C were freerunning in the cage. The rats were killed at the end of the 7thd. The levels of superficial CD11 b / c of neutrophilic granulocyte,reactive oxygen species( ROS) concentration of neutrophilic granulocyte,contents of IL( interleukin)-10,IL-6and TNF( tumor necrosis factor)-α in the blood samples were detected. The superior lobe tissues of right lung were given hematoxylin and eosin stain( HE stain),and the pathological changes of lung tissues in slices were observed. Results In group A,under microscope,the sizes of alveoli were discrepant,the alveolar septum became wide with edema,and blood vessels were dilated and congested,and neutrophils and infiltrated lymphocytes were found in the interstitial. Similar changes of group A were found in group B,but the degrees were less than those in group A,while there were no obviously similar changes in group C. There were statistically significant differences in CD11 b / c,ROS concentration,TNF-α,IL-10 and IL-6( P 0. 05,P 0. 01). Conclusion NAC can alleviate inflammation and lung damages of rats under simulated weightlessness,and the antioxidation effect of NAC may play a role in protection of lung injury under weightless condition." @default.
- W2348908259 created "2016-06-24" @default.
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- W2348908259 date "2015-01-01" @default.
- W2348908259 modified "2023-09-26" @default.
- W2348908259 title "Protective Effect of N-acetylcysteine on Pulmonary Injury under Simulated Weightless Condition in Rats" @default.
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