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- W2348908609 abstract "Recently cytotoxic T lymphocyte associated antigen-4(CTLA 4 Ig)has been regarded as the new and elucidated immunosuppressant in the research of organ transplantation.Immunosuppressive effect has been achieved by CTLA 4 Ig alone.However,pharmacological mechanism of CTLA 4 Ig has not been elucidated.The present studies suggested that CTLA 4 Ig induces immune tolerance after organ transplantation by varied cognate interactions.CTLA 4 Ig affects the production of cytokines(Interleukin-2,Interleukin-10 and so on)and their receptors,switches T cell responses from Th1 to Th2,inhibits the phagocytosis by macrophages,CD8+T cell and dendritic cell,inhibits cell apoptosis and so on.There are many researches on the CTLA 4 Ig and other new immunosuppressants.CTLA 4 Ig respectively correlating with CD40Ig,CD4Ig and TGF-β3 have prolonged the allograft survival than CTLA 4 Ig alone.A long-term graft acceptance also is induced by a combination treatment of donor splenocytes and CTLA 4 Ig in organ transplantation.Simultaneously,more researchers focus on the new carrier of CTLA 4 Ig.CTLA 4 Ig-conjugated liposome will be the more effective carrier than CTLA 4 Ig-gene transfer mediated by adenoviral vector and replication-defective adenoviral vector." @default.
- W2348908609 created "2016-06-24" @default.
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- W2348908609 date "2007-01-01" @default.
- W2348908609 modified "2023-09-22" @default.
- W2348908609 title "Advance of CTLA 4 Ig in the immunotolerance" @default.
- W2348908609 hasPublicationYear "2007" @default.
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