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- W2348929770 abstract "Objective To explore the effect of chronic alcoholism on susceptibility to acute lung injury induced by endotoxin(LPS)in rats. Methods 35 Wistar rats were randomly divided into three groups,they were control group,LPS group and alcoholism+LPS group,then observed the changes of arterial blood gases,wet/dry ratio of lung,and contents of IL-6,VEGF and MCF-1 in lung tissues determined by ELISA at 2 h and 6 h after experiment respectively. Results The results showed that there were obvious decrease in PaO2,PaO2/FiaO2 and VEGF,and obvious increase in wet weight,dry weight,wet/dry ratio of lung,and contents of IL-6,MCF-1 in LPS group and alcoholism+LPS group both at 2 h and 6 h after experiment compared with control group(P 0.01 and 0.05 respectively);at 2 h after experiment,there was some obvious difference between alcoholism+LPS group and LPS group(P 0.05). Conclusions The results suggested that the acute lung injury induced by LPS in chronic alcoholism rats was more severe and susceptible." @default.
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- W2348929770 date "2008-01-01" @default.
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- W2348929770 title "Effect of chronic alcoholism on susceptibility to acute lung injury in rats" @default.
- W2348929770 hasPublicationYear "2008" @default.
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