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- W2348936095 abstract "Objective To understand the effect of PDGFβ receptor pathway on the regulation of pericyte angiogenesis in wound healing,especially in the formation of granulation tissue.Methods The model of cutaneous wound of mouse was created by making full-thickness skin excision,and the PDGFRβ receptor was blocked by the specific antagonist(imatinib mesylate,75mg/kg i.p.).The area of residual wound and the time of wound healing,histological morphology,mean density of microvessel(MVD)as well as the labeling index of pericytes in microvessels were measured by quantification of histological,immunohistochemical and morphological assesses.Results The healing time of the Imatinib mesylate group was obviously delayed for 4 to 5 days compared with the control,and Imatinib mesylate treatment induced a significant greater of residual area of wound since day 1(P0.05).Various pathological changes in wound repair were demonstrated in all of the three phases of wound healing:hemostasis and inflammation,granulation tissue formation and remodeling.The angiogenesis and pericytes were manifested in the phase of granulation tissue proliferation(3-10 days),especially at day 5 and 7.The labeling index of pericytes(MPN)was positively correlated with MVD,but compared with the control group,the MVD and MPN of the Imatinib mesylate group was decreased(P0.05),and accompanied with wider vessel lumen.The number of spindle cells and deposited collagen fibrils in the granulation tissue in Imatinib-treated mice were decreased at the same time.ConclusionsBlocking PDGFβ receptor pathway resulted in delayed wound healing with decreased pericytes and microvessels,suggesting that pericyte was play a significance role in angiogenesis mediated by PDGFβ/PDGFRβ pathway." @default.
- W2348936095 created "2016-06-24" @default.
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- W2348936095 date "2012-01-01" @default.
- W2348936095 modified "2023-09-23" @default.
- W2348936095 title "The effect of PDGFRβ antagonist on regulating the angiogenesis of pericytes in wound healing" @default.
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