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- W2348938833 abstract "Objective To identify functional SNPs in the COX-2 promoter and evaluate its effects on risk of endometriosis.Methods The genomic DNA of each subject was extracted by proteinase K digestion followed by saturated hydroxybenzene/ chloroform procedure.Genotypes of COX-2-1195 promoter of 120 endometriosis cases and 240 controls were examined by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP).Results The frequencies of GG、AG and AA genotype of COX-2-1195 promoter were 14.2%、50.0% and 35.8% in 120 patients with endometriosis,24.6%、53.3% and 22.1% in 240 controls respectively, and there was a significant difference between test cases and controls. A greater risk of developing endometriosis was found for A-1195 containing haplotype as compared with other haplotypes. It was revealed a 1.63-fold (95% CI=0.87-3.03) and 2.82-fold (95% CI =1.44-5.52) excess risk of developing endometriosis in the individual for -1195A and -1195AA containing haplotype respectively.Conclusion The single nucleotide polymorphism of COX-2-1195GC promoter may play an important role in genetic basic to endometriosis." @default.
- W2348938833 created "2016-06-24" @default.
- W2348938833 creator A5050517861 @default.
- W2348938833 date "2007-01-01" @default.
- W2348938833 modified "2023-09-26" @default.
- W2348938833 title "Relationship between functional genetic variations in cyclooxygenase-2 and risk of endometriosis" @default.
- W2348938833 hasPublicationYear "2007" @default.
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