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- W2348957903 abstract "Synthesis of etodolac,a non-steroidal anti-inflammat or y agent, was studied.In the study o-nitroethylbenzene as raw material was r educed by Fe / hydrochloric acid.The intermediate o-ethylaniline could be d iazotized and reduced by sodium sulfite to give o-ethylphenylhydrazine,and 7-ethyltryptophol was obtained by condensation of o-ethylphenylhydrazine a nd 2,3-dihydrofuran in isobutanol as solvent.Finally 7-ethyltryptophol w ithout separation reacted with methyl 3-oxopentanoate and was hydrolyzed to giv e the title compound.The optimal reaction conditions(temperature, time,molar yie ld) were as follows.Reduction of nitro group:reflux,3 h,96.2%;diazotization :0 ℃,0.5 h;reduction of diazonium salt:70—75 ℃,3 h,92.5%(two steps); synthesis of 7-ethyltryptophol:reflux,3 h;preparation of etodolac methyl est er:0 ℃,1.5 h,63.0%(two steps);hydrolysis:reflux,2.5 h,95.0%.The stru ctures of etodolac and its methyl ester were the same as those reported in liter ature." @default.
- W2348957903 created "2016-06-24" @default.
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- W2348957903 date "2005-01-01" @default.
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- W2348957903 title "Synthesis of etodolac" @default.
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