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- W2348966931 abstract "AIM To Evaluate the effect of Mineralocortcoit receptor antagonist (MRA) Spironolactone on post-infarct left ventricular remodeling (LVRD). METHODS One hundred and sixty patients with first anterior AMI were randomly divided into MRA group (n=81) and non-MRA group (n=79). All the patients were given agiotensin-converting enzyme inhibitor(ACEI). The MRA group was treated with Spironolactone combined with routine therapy while the non-MRA group treated only with Spironolactone. Twenty-four hours and 1 month after AMI, left ventricular end diastolic volume Index (LVEDVI), systolic volume index (LVESVI), all notion score index (WMSI) and ejection fraction (LVEF) were detected by ultrasonography. RESULTS At basline, no significant difference of ultrasonography indexs was seen between the two groups. At 1 month after treatment, LVEDVI, LVESVI and WMSI significantly decreased (P0.05), whild LVEF increased in both MRA group and non-MRA group (P0.05), but the improvements in MRA group were better than those in non-MRA group (P0.05). CONCLUSION Routine therapy combined with MRA can more effectively prevent and treat LVRD in patients with AMI." @default.
- W2348966931 created "2016-06-24" @default.
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- W2348966931 date "2008-01-01" @default.
- W2348966931 modified "2023-09-22" @default.
- W2348966931 title "Effect of immediate administration of spironolactone on left ventricular remodelong after acute myocardial infarction" @default.
- W2348966931 hasPublicationYear "2008" @default.
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