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- W2348968810 abstract "Objective To study the efficacy and effect on quality of life of Olanzapine as an Augmentation in treating patients with Refractory Depression.Method 68 patients with refratory depression were randomly assigned to research group(sertraline combined with olanzapine,n=34) and control group(single sertraline,n=34) for 8 weeks.Hamilton Depression rating scale(HAMD),Treatment Emergent symtom scale TESS) were used to assess the efficacy and side effects respectively before treatment and after treatment 1,2,4,6,8 weekends.General quality of life inventory(GQOLI) was analyzed at baseline and the end of the study.Results The therapeutic efficacy in research group was observed at 1 weedend,while in control group at 2 weekend.The scores of HAMD in study group were significant lower than those in control group at 1,2,4,6 weekend(P 0.01).There was no significant difference of score of TESS between the two groups(P 0.05).After 8 weeks treatment,the research group improved obviously the quality of life except the material life factor.Conclusion It is suggested that Olanzapine-assisted treatment of refractory depression,fast onset,may increase the curative effect,be superior to sertraline alone treatment,and improve the patients's quality of life obviously." @default.
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- W2348968810 date "2009-01-01" @default.
- W2348968810 modified "2023-09-23" @default.
- W2348968810 title "Efficacy and effect on quality of life of Olanzapine as an Augmentation in treating patients with Refractory Depression" @default.
- W2348968810 hasPublicationYear "2009" @default.
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