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- W2348969234 abstract "objective:To investigate the effect of antisterone and benazepril combination in the treatment of hypertension and left ventricular hypertrophy and cardiac function. Method: Seventy six cases of hypertension patients with LVH were treated with benazepril 5～10 mg qd and hydrodiuril 25 mg qd. Patients were randomly divided into two groups: Group A( n =38):benazepril and diurectics were combined with antisterone 60 mg qd; Group B( n =38):benazepril and diurectics were used wuth same protocol as group A, while antisterone was replaced by placebo. The patients were examined using 24 h ambulatory BP monitor,echocardiography. The LV mass weight(LVMW) and LVM index(LVMI),LV systolic and diastolic and diameter(LVSd,LVDd),septal thickness(IVST),LV postterior wall thickness (LVPWT),ejection fraction(EF) and E/A ratio were measured. Blood lipid and glucose were monitored before and 6 and 12 months after the treatment. Results:BP was decreased in patients in both groups.The parameters characterized LVH(LVD,LVST,LVPWT,LVMI) were all improved in both groups. E/A and EF were increased accordingly. However,12 months after treatment all LVH parameters showed a more remarkable reversal of LVH in group A than that in group B. The combination treatment had no adverse effects on blood lipid ,glucose ,serum K + and renal function. Conclusion:Antisterone combined with benazepril and lowdose dihydrochlorothiazide was effective in reduction of high blood pressure and reversal of LVH with significant improvement of cardiac function." @default.
- W2348969234 created "2016-06-24" @default.
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- W2348969234 date "2000-01-01" @default.
- W2348969234 modified "2023-09-25" @default.
- W2348969234 title "Effects of Antisterone and Benazepril with Low Dose Hydrodiuril in ;Hypertensive Ventricular Hypertrophy and Cardiac Functions" @default.
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