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- W2348982325 abstract "Aim:The aim was to investigate whether combination of cryotherapy(nitrous oxide) with chemotherapy(Cis-platinum,Cisp) could suppress the development of human gastric cancer cell line SGC-7901 in vivo. Methods: Nude mice injected with doxorubicin-resistant SGC-7901 cells(107),assigned into eight groups of three mice each,challenged with the optimal parameters for combination of cryotherapy(nitrous oxide) with chemotherapy(Cis-platinum,Cisp) and characterised some of the signals involved for apoptosis activation. Results: No advantage appeared when cryotherapy and Cisp were combined simultaneously compared with cryosurgery alone.In contrast,tumour volumes were reduced after a sequential treatment schedule.The sequence of treatment had no impact on the observed tumour growth inhibition in mice,and significant benefit appeared when the sequential treatment was separated by 48 h.The number of apoptotic cells was significantly augmented in the sequential treatment schedule where Cisp was administered 48 h before cryotherapy.In this sequential treatment,the number of apoptotic cells correlated with heightened expression of the Puma,Noxa and Bim at the mRNA level.No significant change in Bax and Bcl-2 mRNA expression was apparent,whereas Mcl-1 expression increased slightly. Conclusion:Data indicate that 48 h sequential rather than simultaneous cryotherapy with Cisp." @default.
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- W2348982325 date "2012-01-01" @default.
- W2348982325 modified "2023-09-25" @default.
- W2348982325 title "Optimization and induction of apoptosis in combination cryotherapy and chemotherapy in human stomach cancer xenografts in SCID mice" @default.
- W2348982325 hasPublicationYear "2012" @default.
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