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- W2348984123 abstract "Objective To observe the ultrastructural changes of human epileptic foci to study the mechanism of epilepsy. Methods EcoG spike foci on the surface of cerebral cortices in 12 cases of intractable epilepsy were removed surgically and studied under electron microscope. Results The ultrastructural changes of the foci were obvious, including the neurons decreasing in number and swelling and degeneration, nuclear pyknosis, marginal collection of heterochromatin; mitochondria swell or disintegrate with mitochondrial cristale vessels or capillaries appear twisted and obstructed, or endothelia cells swell; basement membrane increases in thickness or delamination; astroeytes swell. Conclusion The epileptic loci had obvious pathological changes in all cases, in addition to neurons, synapses, astrocyts, the changes of blood-brain barrier may play an important role in the mechanism of epileptic seizure and the development of epilepsy." @default.
- W2348984123 created "2016-06-24" @default.
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- W2348984123 date "2004-01-01" @default.
- W2348984123 modified "2023-09-23" @default.
- W2348984123 title "Ultrastructural observation on human epileptic foci and studying on the mechanism of epilepsy" @default.
- W2348984123 hasPublicationYear "2004" @default.
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