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- W2348992085 abstract "Objective To investigate the therapeutic effects and mechanism of combined gene therapy of retrovirus mediated herpes simplex virus thymidine kinase(HSV-TK) and costimulatory molecule (B7) for murine mammary cancer. Methods Gene recombinant technique was used to construct retrovirus vector carrying TK/B7 gene. In the murine mammary cancer model of 80 SD mice, GcTKpSN, GcpB7SN and GcTKpB7SN were injected into the tumor directly and respectively. Three days later, GCV was administered intraperitoneally with a dosage of 50 mg.kg -1 .d -1 for 15 days. The CTL activity of spleen cells were determined by using 4 h 51 Cr releasing method. Results Large number of apoptotic cells were found in TK group, lymphocyte infiltration around tumor cells was seen in B7 group and both apoptosis and lymphatic infiltration existed in TK+B7 group. The CTL activity in B7 group (67.4±4.3)% and TK+B7 group (62.1±3.5)% was significantly higher than in in control group (35.6±2.7)% and TK group (39.2±3.8)%. Conclusion The combined gene therapy of HSV-TK and B7 for murine mammary cancer could directly kill tumor and enhance immunogenicity.;" @default.
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- W2348992085 date "2000-01-01" @default.
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- W2348992085 title "Combined gene therapy of B7 and HSV-TK for tumor apoptosis and enhanced immunogenicity in the murine mammary model" @default.
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