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- W2348994113 abstract "Purpose To explore the association between genetic polymorphisms in EPHX1 and EPHX2 and susceptibility to chronic benzene poisoning(CBP). Methods A case-control study of 268 CBP patients and 268 workers occupationally exposed to benzene without poisoning manifestations was conducted.The single nucleotide polymorphisms(SNPs,rs2854451,rs3738047,rs2234922 and rs1051741) of EPHX1 gene and the SNP(rs751141) of EPHX2 gene were tested by the TaqMan PCR method. Results In the subjects carrying genotype of EPHX1 rs373804 GG,the risk of CBP decreased for the individuals with allele of EPHX1 rs2234922 G(P=0.02).Alternatively,in the subjects carrying genotype of EPHX1 rs2234922 AA,the risk of CBP increased for the subjects with allele of EPHX2 rs751141A(P=0.03).Potential interactions were found between alcohol consumption and polymorphism of EPHX1 rs1051741(χ~2____H=5.28,P=0.02) or rs2234922(χ~2____H=6.71,P=(0.01)).Compared to individuals with EPHX1 rs1051741 CC or rs2234922 AA genotype in the drinkers group,the risk of CBP for the subjects carrying genotypes of EPHX1 rs1051741 CT+TT or rs2234922 AG+GG was decreased,respectively(P=0.04,P0.01).Haplotypes analysis of polymorphisms in EPHX1 showed that the risk of CBP increased for the subjects with haplotype 2(rs2854451-A,rs3738047-G,rs2234922-A,rs1051741-C) or haplotype 4(rs2854451-G,rs3738047-A,rs2234922-G,rs1051741-T),but decreased for the subjects with haplotype 6(rs2854451G,rs3738047-G,rs2234922-G,rs1051741-T) or haplotype 10(rs2854451-A,rs3738047-A,rs2234922-G,rs1051741-T),respectively.Logistic regression analysis showed that smoking may play a role in modifying the risk of chronic benzene poisoning(OR=0.313,95%CI:0.123-0.794,P=0.015). Conclusions Genetic polymorphisms in EPHX1 may be associated with the risk of CBP,and further research is needed for the association between genetic polymorphisms in EPHX2 and susceptibility to CBP." @default.
- W2348994113 created "2016-06-24" @default.
- W2348994113 creator A5069794187 @default.
- W2348994113 date "2006-01-01" @default.
- W2348994113 modified "2023-09-25" @default.
- W2348994113 title "Association of genetic polymorphism of EPHX1 and EPHX2 with risks of chronic benzene poisoning" @default.
- W2348994113 hasPublicationYear "2006" @default.
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