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- W2348996818 abstract "A thermosensitive, injectable in situ gelling formulation was developed using naturally biodegradable chitosan hydrogel. The release profiles of a low water solubility drug, 5-fluorouracil (5-Fu, an antineoplastic agent, using this formulation were then characterized. The rapid initial release of the drug was controlled by first microencapsulating the drug, and then mixing the microparticles with the thermosensitive gel. The microparticles were prepared by the solvent/non-solvent method, using biodegradable poly-3-hydroxybutyrate (PHB as the scaffold to capsulate the 5-Fu. At an optimized drug to scaffold ratio, the recovery rate of the microparticles was over 90%, with an encapsulation efficiency of over 95%. The chitosan hydrogel containing these microparticles can accurately control the rapid initial release of the drug to give 10 months of sustained release." @default.
- W2348996818 created "2016-06-24" @default.
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- W2348996818 date "2005-01-01" @default.
- W2348996818 modified "2023-09-27" @default.
- W2348996818 title "Thermogelling implant drug delivery system with poly-3-hydroxybutyrate based on microparticles" @default.
- W2348996818 hasPublicationYear "2005" @default.
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