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- W2349006073 abstract "Objective To observe the effects of Ganoderma lucidium spore on oxidative stress and inflammatory responses in rats with Parkinson' s disease( PD). Methods The PD model rats were induced by injecting 6-hydroxydopamine(6-OHDA) into the right striatum. G anoderma lucidium spore(25 g / kg) was given orally once daily for 30 days. The contents of malondialdehyde( MDA),glutathione( GSH),nitric oxide( NO),tumor necrosis factor-α( TNF-α),and the activity of superoxide dismutase( SOD),glutathione-peroxidase( GSH-PX) in the brain tissues were detected respectively. Results After treatment,G anoderma lucidium spore can decrease the levels of MDA, NO and TNF-α obviously,and increase significantly the activity of SOD,GSH-PX and the content of GSH( P 0. 05 or 0. 01). Conclusion The protective effect of G anoderma lucidium spore against 6-OHDA-induced brain injury of PD model rats may rely on its ability to reduce oxidative stress and suppress inflammatory responses." @default.
- W2349006073 created "2016-06-24" @default.
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- W2349006073 date "2014-01-01" @default.
- W2349006073 modified "2023-09-26" @default.
- W2349006073 title "Effect of Ganoderma lucidium spore on oxidative stress and inflammatory responses in rats with parkinson's diseas" @default.
- W2349006073 hasPublicationYear "2014" @default.
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