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- W2349016430 abstract "Objective To observe the CD40 L expression on peripheral blood mononuclear cells (PBMC) and the intervention factors in children with henchschnlein purpura (HSP), and explore the pathogenesis and possible therapy for HSP Methods The cells count of CD40 L expression in PBMC were determined by flow cytometry IgA, IgG, IgM, IgE and IL4, IL5 were detected by radial immunodiffusion and ELISA Results The serum IgA and IgE levels, CD40 L positive cells, and IL4 and IL5 levels in the supernatants of cultured PBMC of HSP patients were increased significantly in contrast to the normal controls The elevated levels of IL4 and IL5 in the cultured PBMC could be corrected when antiCD40 L monoclonal antibody (mAb) or cyclosporin A(CsA) was added in vitro Conclusion The abnormal expression of CD40 L might relate to the pathogenesis of HSP AntiCD40 L mAb and CsA could intervene PBMC of HSP in vitro, which might indicate a possible immunotherapy way for HSP in the future" @default.
- W2349016430 created "2016-06-24" @default.
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- W2349016430 date "1999-01-01" @default.
- W2349016430 modified "2023-09-23" @default.
- W2349016430 title "The expression of CD40 L in PBMC and the intervention factors in children with HenchSchnlein purpura" @default.
- W2349016430 hasPublicationYear "1999" @default.
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