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- W2349043930 abstract "The interaction between farrerol and calf thymus DNA(ctDNA) was explored by UV-visible spectrophotometry,fluorescence spectroscopy,and melting-point technique in combination with methylene blue(MB) competition in the presence of Cu2+,Co2+ and Mg2+ in physiological buffer(pH 7.4).The results revealed that farrerol could be intercalatively bound to DNA.Cu2+,Co2+ and Mg2+ had different effects on the absorption spectrum of farrerol and could increase the fluorescence intensity of DNA-MB complex.A gradual increase in Cu2+ concentration could result in an initial decrease followed by an increase in the binding constant of DNA-farrerol complex.In the presence of higher Mg2+ concentration,the binding constant of DNA-farrerol complex tended to initially increase and then decrease.However,Increasing Co2+ concentration revealed little effect on the binding constant of DNA-farrerol complex.Therefore,the effect of metal ions on the binding between farrerol and DNA mainly depends on the relative affinity between metal ions and farrerol,DNA basic groups or phosphate groups." @default.
- W2349043930 created "2016-06-24" @default.
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- W2349043930 date "2011-01-01" @default.
- W2349043930 modified "2023-09-27" @default.
- W2349043930 title "Effects of Cu~(2+),Co~(2+) and Mg~(2+) on Interaction between Farrerol and DNA" @default.
- W2349043930 hasPublicationYear "2011" @default.
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