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- W2349048353 abstract "Objective To compare the characteristics of EAE animal models induced with different immunogens in DA and Lewis rats.Methods DA rats were immunized with MOG_(35-55) or homogeneous spinal cord(homogenate)(DA-SCH),and Lewis rats with guinea pig MBP(GP-MBP) or MBP_(68-86)to induce EAE.The clinical course,the severity and histopathology were observed and compared between twe different animal models.(Results)EAE induced in DA rats with MOG_(35-55) or DA-SCH manifested an remitting-relapsing biphase course,whereas Lewis rats with GP-MBP or MBP_(68-86)showed_()an acute monophase course.GP-MBP model was characterized by a relatively synchronous onset of the disease with high incidence and severity.The severity of DA-SCH model was next only to the above one,but the onset time in the group was not even.The clinical status in MOG_(35-55) and MBP_(68-86)groups were milder.While in all groups,the main histopathology change at the peak of the illness was an inflammatory response,in DA rats at the second phase,the inflammation was relatively mild but demyelination was prominent.Conclusions EAE models induced with different immunogens has different characteristics,and therefore can be selectively used in various studies." @default.
- W2349048353 created "2016-06-24" @default.
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- W2349048353 date "2005-01-01" @default.
- W2349048353 modified "2023-09-28" @default.
- W2349048353 title "A Comparison of Experimental Autoimmune Encephalomyelitis Animal Models" @default.
- W2349048353 hasPublicationYear "2005" @default.
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