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- W2349072610 abstract "Objective:To investigate the growth inhibitory effect of cartilage polysaccharide on L1210 leukaemia mice, and discuss its anti-tumor mechanism.Methods:DBA/2 mouse model was established using mouse L1210 ceils,mice were divided into control group,low-dose group,middle-dose group and high-dose group,mice were treated by i.p.injection of cartilage polysaccharide,body weight was measured very day and survial time was recorded,increase of lifespan was calculted.Ceil cycle analysis were performed using ascites got from the mouse in treated group at 0 h,24 h,48 h and 72 h.HE staining were carried out to observe the changes of morphology.The expression of BAD and BCL-2 protein was studied by immunofluorescent technology to explore the anti-tumor mechanism of cartilage polysaccharide.Results:The survival rate of L1210-bearing mice increased significandy by treatment of cartilage polysaccharide.Gell shrinkage,nuclear condensation and apoptotic body could be detected by cell morphological observation.The cell cycle of L1210 cells which treated by cartilage polysaccharide was blocked in G0/G1 phase,and the apoptotic rate significantly increased during the stage of 24-48h.The expression of Bad protein was up- regulated from 24h to 72h after treatment of cartilage polysaccharide as well as the expression of Bcl-2 expression was low- regulated.Conclusions:Apoptosis of L1210 cells can be induced by cartilage polysaccharide through the effect on cell cycle and the expression of BAD and BCL-2 protein,and the great inhibition on tumor ceil growth.As a result the survival time of L1210- bearing mice are prolonged.It can be concluded that cartilage polysaccharide is a novel anti-tumor agent." @default.
- W2349072610 created "2016-06-24" @default.
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- W2349072610 date "2007-01-01" @default.
- W2349072610 modified "2023-09-26" @default.
- W2349072610 title "Study on Growth Inhibitory Effect of Cartilage Polysaccharide on L1210 Leukaemia Mice" @default.
- W2349072610 hasPublicationYear "2007" @default.
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