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- W2349076958 abstract "Objective To establish an animal model of Alzheimer's disease(AD) and observe the therapeutic effect of saponins of polygala on learning and memory and activities of AchE and ChAT.Method The 70 rats were randomly divided into seven group as following: model group,saponins of polygala groups respectively at high,moderate and low doses,Donepezil Hydrochloride tablets group,sham-operation group and normal group.The amyloid-β25-35 was injected into the hippocampus to induce learning and memory dysfunctions in rats,after 5 weeks with medicine intervention,the learning and memory abilities were measured by water-maze;the activities of AchE and ChAT were detected by spectrophotometer.Results Compareed with the model group,the times of entering the blind-end were obviously decreased and swimming time was obviously shortened,the activity of ChAT wasincreased and the activitiy of AchE decreased in treatment groups(P0.01 or 0.05).Conclusion Saponins of polygala can improve the ability of learning and memory in AD model rats and the mechanism maybe is related to protect the central cholinergic system." @default.
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- W2349076958 date "2009-01-01" @default.
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- W2349076958 title "Effect of saponins of polygala on learning, memory and activities of AchE and ChAT in hippocampus in AD Rats" @default.
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