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- W2349104344 abstract "Background and purpose:Blood vessel metastasis often occurs after the operation of rectal cancer of stage Ⅱ and Ⅲ,angiogenesis is an important step of the procedure.Cycloxygenase-2(COX-2) and vascular endothelial growth factor(VEGF-C) are correlated to angiogenesis. The purpose of this study is to investigate the expressions of Cycloxygenase 2(COX-2) and vascular endothelial growth factor(VEGF-C) in rectal cancer of stage Ⅱ and Ⅲ,to explore the relationships between them and the tumor biological characteristics,tumor angiogenesis.Methods:The expressions of COX-2,VEGF-C and the microvessel density(MVD) were detected by immunohistochemical staining.Results:①The positive rates of COX-2 and VEGF-C expression in rectal cancer were 72.5%,higher than those in peritumoral normal tissue(P(0.05)).The value of MVD in cancer was 18.41±8.859,higher than the value in peritumoral normal tissue(P(0.05)).②The expression of COX-2 was correlated with the expression of VEGF-C,and also correlated with the differentiation of the tumor and the depth of the invasion,it was not correlated with the lymph node metastasis and the size of the tumor.③The expression of VEGF-C was correlated with the expression of COX-2 only but not with the lymph node metastasis,the size of the tumor,the differential of the tumor and the depth of the invasion,④The value of MVD was correlated with the expression of COX-2,VEGF-C,and the differentiation of the tumor,but not with the lymph node metastasis,the size of the tumor and the depth of the invasion.Conclusions:The expressions of COX-2 and VEGF-C in stage Ⅱ and Ⅲ rectal cancer may be related to tumor angiogenesis,but have no relationship with prognosis." @default.
- W2349104344 created "2016-06-24" @default.
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- W2349104344 date "2006-01-01" @default.
- W2349104344 modified "2023-09-26" @default.
- W2349104344 title "The expressions of COX-2 and VEGF-C in stage II and III rectal cancer and its association with angiogenesis and prognoses" @default.
- W2349104344 hasPublicationYear "2006" @default.
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