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- W2349115256 abstract "OBJECTIVE:To summarize the research of Smad4 in common malignant tumors of the digestive system home and abroad.METHODS:By PUBMED and CNKI retrieval system,withSmad4 and pancreatic cancer,esophageal squamous cell carcinoma,gastric cancer et al.as the key words,160 papers of literature in English and 45 in Chinese on Smad4 were retrieved from 01,1996 to 01,2009.The selection standards for the data related to SM-AD4:1)domain and function of signal transduction and regulation of Smad4;2)the expression of Smad4 in common malignant tumors of the digestive system;3)tumor progression associated with loss expression of Smad4;4)targeting Smad4 as an anticancer therapy.According to the above standards,85 documents were selected and 25 were finally analyzed.RESULTS:Smad4 gene as a tumor suppressor plays a crucial role in pancreatic cancer and gastrointestinal adenocarcinoma tumor,besides,the lack of the expression of Smad4 has a negative correlation with the development of these tumors.However,it is inconsistent that Smad4 gene transcription and its protein expression level,and relevant research literature few between loss expression of Smad4 protein and the grade and stage in esophageal squamous cell carcinoma.CONCLUSION:Further research on the expression and function of Smad4 in the common malignant tumors of the digestive system,especially in the esophageal squamous cell carcinoma will contribute to extensity understanding the molecularmechanism of tumor invasion and metastasis and acquire an important breakthrough in cancer targeted therapy." @default.
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- W2349115256 date "2009-01-01" @default.
- W2349115256 modified "2023-09-23" @default.
- W2349115256 title "Research progress of Smad4 in common malignant tumor tissues of digestive system" @default.
- W2349115256 hasPublicationYear "2009" @default.
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