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- W2349125671 abstract "Objective To explore the changes of serum leptin level in patients with chronic heart failure (CHF) and the relationship between leptin and insulin resistance and hyperinsulinemia. Methods Leptin levels were studied in 40 male patients with CHF and 20 male normal controls. The relationships between serum leptin level and insulin resistance and insulin concertration were also analyzed. Results Compared with the control group, CHF group had significant increased serum leptin level [( 6.1± 2.1)μg/L vs( 3.8± 1.1)μg/L, P 0.01], higher fasting insulin levels[(18±3) mU/L vs (10±2) mU/L, P= 0.02] and higher degree of insulin resistance (indicated by IAI, 4.4± 0.6 vs 3.8± 0.7, P 0.01). Serum leptin level correlated with fasting insulin and (IAI) (r= 0.803, 0.716, P 0.01, respectively). Conclusion Serum leptin levels increase in patients with CHF. There are positive relationships between serum leptin and insulin concentration and insulin resistance, indicating a possible role of insulin-leptin axis in the increased energy expenditure observed in patients with CHF." @default.
- W2349125671 created "2016-06-24" @default.
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- W2349125671 date "2004-01-01" @default.
- W2349125671 modified "2023-09-23" @default.
- W2349125671 title "Relationship between hyperleptinaemia and insulin resistance in patients with chronic heart failure" @default.
- W2349125671 hasPublicationYear "2004" @default.
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